![]() ![]() However, it is not known whether central obesity associates with DPN independently of BMI in type 2 diabetes. Accordingly, central obesity has been shown to be a stronger predictor of some diabetes complications than-and independently of-BMI ( 13). Some individuals who are obese by BMI criteria (BMI >30 kg/m 2) can be metabolically healthy ( 11), which can possibly be attributed to less visceral fat distribution ( 12). Visceral fat accumulation associates with metabolic dysfunction, e.g., low-grade inflammation, insulin resistance, and dyslipidemia. Increasing evidence supports an association between the degree of obesity and risk of DPN in type 2 diabetes ( 6– 10), but the exact biological mechanisms remain unclear. Smoking, high alcohol intake, and failure to increase activity after diabetes diagnosis associated with neuropathic pain. ![]() Smoking, aPR 1.50 (95% CI 1.24 1.81), and lack of physical activity (0 vs. In regression analyses, central obesity (waist circumference, waist-to-hip ratio, and waist-to-height ratio) was markedly associated with DPN. Among 5,249 patients with data on both DPN and pain, 17.9% ( n = 938) had possible DPN, including 7.4% ( n = 386) with possible neuropathic pain. ![]()
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